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CombiGene om Världsepilepsidagen och läkemedelsmyndigheternas positiva svar #lifesciences #BioStockSwe @CombiGene

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Combigene är ett forskningsbolag. Idag fokuserar bolaget på att utveckla nya behandlingar avsedda för olika neurologiska sjukdomar. Störst fokus ligger inom behandling utav epilepsi, men även behandling av övriga nervsjukdomar förekommer.

Redpin Therapeutics AAV vector Epilepsy – not defined: Preclinical. Research group from UCL AAV vector containing Kv1.1 -based potassium channel Focal In 2021, CombiGene's epilepsy project CG01 will focus on the final preclinical studies. In parallel, the company will intensify preparations for studies in humans, known as clinical studies, which are scheduled to begin in 2022. Today, CombiGene successfully completed the first large-scale production of its drug candidate CG01, which is being developed for the treatment of drug-resistant focal epilepsy. An agreement was also signed during the week with British Neurochase to optimise the injection strategy and maximise the safety and effect of CG01, which is to be injected directly into human brain tissue. CombiGene 's candidate drug, CG01, is being developed for treatment of patients with drug-resistant focal epilepsy. The aim is to enable a very long-term therapeutic effect through a one-time administration.

Combigene epilepsy

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3 september, 2020. Today CombiGene announced the signing of a production agreement with the Spanish gene therapy manufacturer Viralgen for the production of the drug candidate CG01. The choice of partner is based on the fact that Viralgen can manufacture the candidate on a large scale, which means both cost savings and faster development of CG01, a gene therapy developed for the treatment of patients with drug-resistant focal epilepsy. The outcome entails that CombiGene can advance its pipeline programs toward the potential value inflection points arising out of the final parts of CombiGene’s preclinical program for CG01 and in vivo studies in the lipodystrophy project CGT2. The subscription period in the Rights Issue was completed on 31 March 2021. Collaboration supports progression of Epilepsy Gene Therapy toward clinical trials. CombiGene AB (publ), a leading Nordic gene therapy company, today signed an agreement with the Anglo-Swedish Contract Development and Manufacturing Organisation (CDMO) Cobra Biologics for production of candidate drug CG01.

28 jan 2016 CombiGene / Nyheter på CombiGenes hemsida / Nyheter på CombiGenes hemsida. 2016-01-28 16:08. Article about Epilepsy: The Pipeline

People who have epilepsy have ele Epilepsy is a condition that has been known to mankind since ancient times. Cobra Biologics successfully produced master cell banks for CombiGene's gene   24 Aug 2020 CombiGene AB (publ) has recently completed a successful pilot production of CombiGene's work in epilepsy brings great hope for patients  Executive Summary. CombiGene AB (publ) engages in the development of methods for the treatment of epilepsy and other neurological diseases. More Details  14, Automated Detection of Epileptic Lesions from MRI, CorticoMetrics, 32, CG101, Combigene, pre, /N/A, Gene Therapy, Focal Epilepsy, N/A, N/A, N/A, N/A   2 Apr 2020 completes key milestone in CombiGene's epilepsy project CG01 with therapy drug candidate aimed at treating drug resistant focal epilepsy.

Combigene epilepsy

Last week, CombiGene reported that the company’s two warrants were exercised at 98.4 percent, which thus added just over SEK 25 million to the company. In addition, one of the company’s co-founders, Associate Professor David Woldbye, published a peer-reviewed article in Frontiers in Molecular Neuroscience, concerning CombiGene’s epilepsy project CG01.

2015-12-11 00:31, Edited at: 2015-12-11 00:37 Views: 312.

Cobra Biologics, part of the Cognate BioServices family and CombiGene announced Cobra has successfully produced and supplied two further DNA plasmids for the production of CombiGene’s gene therapy drug candidate CG01, which is being developed for the treatment of drug-resistant focal epilepsy.
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Combigene epilepsy

10th Sep 2020. Gene Therapy , CombiGene , plasmid dna , CG01 , epilepsy. The agreement is part of preparations for GMP production of material for the first clinical study of CG01. Cobra Biologics, part of the Cognate BioServices family, an international CDMO manufacturer of biological materials and pharmaceuticals, and CombiGene AB (publ), the leading gene therapy company in the Nordic region, today announced that they have signed agreements covering Good Manufacturing Practice (GMP CG01 is CombiGene’s lead project, targeting pharmacoresistent focal epilepsy. Epilepsy is the fourth most common neurological disorder, affecting around 65 million people worldwide, and is characterised by seizures, which are caused by the abnormal firing of neurons in the brain.

Epilepsy. Description  3 days ago It focuses on the research of therapy for patients with epilepsy.
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Panion Animal Health AB's aim is to develop and commercialize a gene therapy treatment for dogs with drug refractory epilepsy based on CombiGene AB's 

Foundation for future commercial supply of CG01 secured with delivery of three Master Cell Banks Combigene. 179 likes · 20 talking about this. Biotechnology Company “CombiGene is in an exciting development phase. In 2021, we are taking important steps with the epilepsy project CG01, which means that we plan to start the first clinical study next year.


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new methods for the treatment of neurological diseases and for epileptic patients who cannot be  Jan 17, 2018 The company says initial data from the preclinical proof-of-concept-study, show that CombiGene's CG01 reduces the frequency of epileptic  Sep 15, 2020 development of quality control analytical assays for clinical production of CombiGene's AAV-based gene therapy for the treatment of epilepsy  CombiGene AB engages in the development of new treatment for neurological diseases. It focuses on the research of therapy for patients with epilepsy. Oct 8, 2020 It focuses on the research of therapy for patients with epilepsy. The company was founded by Lars Thunberg, Merab Kokaia and David Woldbye  May 23, 2018 CombiGene was granted 3,3 million euro in the latest Phase 2 round in company's gene therapy project focusing on difficult-to-treat epilepsy. Oct 21, 2019 CombiGene is developing a breakthrough gene therapy with potential to dramatically improve the quality of life for a group of epilepsy patients  Pyridoxine-dependent epilepsy (PDE) is a rare cause of stubborn, difficult to control, (intractable) seizures appearing in newborns, infants and occasionally older  Pyridoxine-dependent epilepsy is a condition that involves seizures beginning in infancy or, in some cases, before birth.

Den New York-baserade affärsutvecklingskonsulten Lacerta Bio kommer att skriva och publicera en serie artiklar om epilepsi, genterapi och närliggande ämnen 

{{ chapter.name }}  The CG01 epilepsy project CombiGene’s epilepsy project reaches milestones according to plan. CombiGene has conducted a wide range of preclinical Human expression study confirms that human brain cells take up CombiGene’s drug candidate. In the last quarter of 2017, Learning and memory study CombiGene – the leading Nordic gene therapy company. CombiGene is currently conducting two gene therapeutic development projects: one for treatment of epilepsy that cannot otherwise be treated with drugs and one for treatment of lipodystrophy, a rare condition characterized by an abnormal distribution of fatty tissue in the body.

Cobra Biologics will produce the AAV viral vector for Combigene’s epilepsy gene therapy from its facilities in Keele, UK. Nordic gene therapy company Combigene’s CG01 candidate is based on an adeno-associated viral vector (AAV) which administers a combination of neuropeptide Y (NPY) and its receptor Y2 directly to the part of the brain where epileptic seizures begin. Cobra Biologics, part of the Cognate BioServices family and CombiGene announced Cobra has successfully produced and supplied two further DNA plasmids for the production of CombiGene’s gene therapy drug candidate CG01, which is being developed for the treatment of drug-resistant focal epilepsy.